Against Eubanks, Sinner hit 12 aces and recorded four out of 12 break points to win the match 6-4, 7-6 (10-8), 6-2.
Medvedev, who is yet to drop a set so far in the competition, made short work of Wu Yibing in the third round.
Ons Jabeur and Veronika Kudermetova are scheduled to face one another in a round of 16 match of the US Open 2022 on Sunday, September 4.
Cori Gauff vs Shuai Zhang are scheduled to face one another in a round of 16 match of the US Open 2022 on Sunday, September 4.
Caroline Garcia and Alison Riske are scheduled to face one another in a round of 16 match of the US Open 2022 on Sunday, September 4.
Casper Ruud vs Corentin Moutet are scheduled to face each other on Sunday, September 4 in the round of 16 of the 2022 US Open.
Matteo Berrettini vs Alejandro Davidovich are scheduled to face each other on Sunday, September 4 in the round of 16 of the 2022 US Open.
Pablo Carreno Busta vs Karen Khachanov are scheduled to face each other on Sunday, September 4 in the round of 16 of the 2022 US Open.
For the first time in six years, the 2012 champion won 14 of the final 15 games to advance to the third round in New York.
The Tunsian picked up a 7-5, 6-2 win over Brengle, scoring five aces and converting six out of eight break points.