Throughout the match, De Minaur faced shouts and jeers from the patriotic home crowd, whose songs and applause for Gaston helped him to victory.
The match ended with Hugo Gaston recording an unlikely victory over Alex de Minaur by a score-line of 4-6, 6-2, 6-3, 0-6, 7-6 (10-4).
At Roland-Garros, the world No. 154 defeated Russian Aslan Karatsev 6-3, 4-6, 6-4, 3-6, 7-6 (5) and will now face Canadian Felix Auger-Aliassime.
On Friday, the ATP Tour stated that ranking points will no longer be used in this year's Wimbledon.
He has ruled out returning to Wimbledon this summer as he works to restore his health, but he still intends to return to the capital.
Ramanathan has moved on to the second round of the qualifiers where he will go up against France's Sean Cuenin on Wednesday.
As Novak Djokovic beat Stefanos Tsitsipas in the final of the Italian Open, his son, Stefan, won a club competition in Serbia.
Emma Raducanu was forced to withdraw from the 2022 Italian Open due to a physical ailment after she was ousted in the first round.
Swiatek was forced to drop from the Madrid Open in April due to a shoulder ailment, but she was at her best against Sabalenka on Saturday.
The reigning Madrid Open champion went a set down in the match but came back from what seemed like a dire situation to move on to the semis.