Ramos-Vinolas secured his place in the last four after a breezy victory against another Spanish athlete, Pedro Martinez.
Dominic Thiem defeated compatriot Sebastian Ofner in the round of 16 by a score of 6-2, 2-6, 6-3.
The second round of the 2022 ATP Generali Open will take place on Wednesday, and the rapidly improving Dominic Thiem will face fellow Austrian and 235th-ranked Sebastian Ofner.
Sousa defeated Vit Kopriva in the round of 32 of the competition by a score of 6-1, 7-5 in which he hit six aces and won five out of nine break points.
Ramos-Vinolas has been in good form of late, reaching the semi-final of the recently concluded Swiss Open where he lost to top seed Casper Ruud.
Roberto Bautista Agut and Jurij Rodionov will take on each other on Wednesday, July 27 in the round of 16 of the 2022 Generali Open.
At the Swedish Open, Thiem went as far as the quarter-final, defeating the likes of Emil Ruusuvuori and fourth seed Robert Bautista Agut.
Aslan Karatsev and Dusan Lajovic will take on each other on Wednesday, July 27 in the round of 16 of the 2022 Generali Open.
Against Andujar, Ramos-Vinolas has won four and lost 10. The Spaniard will be hoping to turn that record around, one match at a time.