Djokovic's last competition was the Laver Cup which saw him play a couple of matches and come out with a 50-50 record.
Against Andujar, Ramos-Vinolas has won four and lost 10. The Spaniard will be hoping to turn that record around, one match at a time.
On paper, Norrie should have a simple victory against the Andujar but you never know when it comes to tennis.
The most eye-catching fixture of all on the opening day was the one between Dusan Lajovic and fifth seed Frances Tiafoe.
On the back of a comfortable first-round win at Roland Garros, the Swiss maestro feels he’s “getting better every month”.
The Frenchman prevailed over Brazilian Thiago Seyboth Wild in a tightly-fought match in Lyon.
The Swiss maestro is happy to be back on the court but was disappointed with the result at the Gonet Geneva Open.
The Spaniard won the match 6-4, 4-6, 6-4 in a match where it seemed at one point that victory would be comfortable for Federer.