Dominic Thiem defeated compatriot Sebastian Ofner in the round of 16 by a score of 6-2, 2-6, 6-3.
Sousa defeated Vit Kopriva in the round of 32 of the competition by a score of 6-1, 7-5 in which he hit six aces and won five out of nine break points.
Ramos-Vinolas has been in good form of late, reaching the semi-final of the recently concluded Swiss Open where he lost to top seed Casper Ruud.
At the Swedish Open, Thiem went as far as the quarter-final, defeating the likes of Emil Ruusuvuori and fourth seed Robert Bautista Agut.