John Isner has been in good form in the recent past, reaching the semi-final of the recently concluded Hall of Fame Open.
At the Championships, Opelka was beaten in the second round by Dutch sensation Tim van Rijthoven in what was an absolute classic.
On Wednesday, an interesting second-round matchup between Tommy Paul and Kwon Soon-woo will take place at the 2022 Atlanta Open.
Frances Tiafoe will play qualifier Taro Daniel in the second round of the 2022 Atlanta Open after receiving a first-round bye.
The Atlanta Open's second round will feature Australian John Millman versus home favourite Brandon Nakashima.
At the 2022 ATP Atlanta Open, Australian Thanasi Kokkinakis will play American Andres Martin in the opening round on Wednesday.
On Wednesday, the Australian James Duckworth will face German Dominik Koepfer in the opening round of the 2022 ATP Atlanta Open.
Ramanathan Ramkumar, ranked 229th in the world, will play Ben Shelton, a wildcard entry from the United States, in the opening round of the 2022 ATP Atlanta Open on Tuesday.
On Monday, the 2022 ATP Umag Open's first round will feature the World No. 91 Mikael Ymer of Sweden taking on Jaume Munar of Spain.
Ilya Ivashka and Quentin Halys will take on each other on Tuesday July 26 in the first round of the 2022 Atlanta open.