Opelka won the 2015 Junior Wimbledon tournament, defeating Junior world No. 1 Taylor Fritz en route to defeating Mikael Ymer in the final.
On Friday, in the third round of 2022 ATP Citi open Nick Kyrgios of Australia will face Reilly Opelka of America in a thrilling match.
On Wednesday, Reilly Opelka, rated 17th in the world, will play Denis Kudla, an 82nd-ranked American, in the second round of the 2022 ATP Citi Open.
At the Championships, Opelka was beaten in the second round by Dutch sensation Tim van Rijthoven in what was an absolute classic.
Reilly Opelka beat the veteran tennis player 6-3, 7-6 (9-7) for his fourth ATP Tour title and his maiden Tour title on clay.
With his 6-3, 7-5 victory, the American advances to his third tour-level final of the season, all of which have taken place on American soil.
It will be the sixth time Opelka and Isner meet and the match promises to be a fine encounter of youth against experience.
Rafael Nadal will face Nick Kyrgios and Cameron Norrie will face Carlos Alcaraz Garfia in the quarter-finals on Friday.
Amazingly, he won his first-ever match on tour - and that win came against an established name in Pablo Carreno Busta.