At the Championships, Opelka was beaten in the second round by Dutch sensation Tim van Rijthoven in what was an absolute classic.
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Top seed Reilly Opelka will begin his 2022 Atlanta Open campaign against Ilya Ivashka in the round of 16. Opelka has not been a part of any major competition since the Wimbledon Championships so he might have a tricky tima against his compatriot. At the Championships, Opelka was beaten in the second round by Dutch sensation Tim van Rijthoven in what was an absolute classic. With the US Open a little more than a month away, Opelka will be hoping to make it count in Atlanta. However, he will have his work cut out against a veteran in the form of Ilya Ivashka. The Belarusian defeated Quentin Halys in the round of 32 of the Atlanta Open. He was not a part of Wimbledon but at Hertogenbosch, Ivashka went as far as the quarter-finals.
Reilly Opelka and Ilya Ivashka will take on each other on Thursday, July 28 in the round of 16 of the 2022 Atlanta Open. The competition is scheduled to commence on July 25 and conclude on July 31 this year.
| Player | Seed |
| Reilly Opelka | 1 |
| John Isner | 2 |
| Alex De Minaur | 3 |
| Francis Tifoe | 4 |
| Tommy Paul | 5 |
| Jenson Brooksby | 6 |
| Nick Kyrgios | 7 |
| Brandon Nakashima | 8 |
The Atlanta Open 2022 will have five rounds of play, not including the qualifiers. There are the first round, round of 16, quarter-final, semi-final, and final. Here is the schedule for each stage of the ATP 250 competition.
| Competition stage | Dates |
| First round | July 25 and 26 |
| Round of 16 | July 27 and 28 |
| Quarter-final | July 29 |
| Semi-final | July 30 |
| Final | July 31 |
Here is a list of broadcasters covering the 2022 Atlanta Open
