With form and confidence on his side, it looks like the 34-year-old is the man to beat for the highly anticipated tournament in the French capital.
As Novak Djokovic beat Stefanos Tsitsipas in the final of the Italian Open, his son, Stefan, won a club competition in Serbia.
The Norwegian Ruud came out as the victor after what was a thrilling contest that saw a brilliant tie-break in the very first set.
Day six saw third seed Rafael Nadal eliminated by Canada's Denis Shapovalov who recorded a fantastic comeback win.
After beating second seed Alexander Zverev 6-3, 6-1, the 19-year-old mentioned that it was watching Rafa win this particular title as he was growing up that inspired him.
Murray defeated Dominic Thiem, the 2020 US Open champion, in the first round of the tournament before defeating Denis Shapovalov of Canada.
At the age of 20, he disrupted Roger Federer's and Rafael Nadal's streak of 11 consecutive majors to win his first Grand Slam title
Djokovic has held the No. 1 ranking for a record 338 weeks and has concluded the year as the ATP year-end No. 1 on a joint-record six occasions.
At the ATP 250 clay-court event, the second seed dug deep against Djokovic, hitting with relentless power and intensity to outlast the home favourite.
Both Rublev and Djokovic have had to fight past some tough competition but they had also been dealt a fair share of comfortable wins.