Jessica Pegula is perhaps the most prolific American player at the tournament and she will be hoping for a positive performance.
The Spaniard could not display a good performance at Roland Garros, nor has she made any great bounds on grass so far.
At the Bad Homburg Open, Anisimova did quite well to reach the quarter-finals but was defeated at that stage by Paula Badosa.
Leading up to The Championships, Haddad-Maia participated in three grass court competitions and won two.
Anett Kontaveit will face American tennis player Bernarda Pera in the first round of the competition to get her campaign underway.
Seeded seventh in the tournament, Danielle Collins will be coming into the tournament underprepared on grass.
Ever since she became the US Open champion, Raducanu has not been able to make a mark in world tennis.
Tsitsipas was beaten in the quarter-final of the Stuttgart Open by a spirited Andy Murray and was ousted at Halle by Nick Kyrgios in the round of 16.
Van Rijthoven beat second seed Auger-Aliassime in the semis and finally top seed Medvedev in the final of the Rosmalen Championships.
Against all odds, the 36-year-old Spanish legend emerged victorious both in Australia and Paris to take his Grand Slam tally to 22.