Arsenal are placed at the top of Group A with 12 points, while PSV are second with seven points from four matches.
PSV Eindhoven have been on a decent run domestically as they are placed second in Eredivise with 24 points from 11 games.
Placed in Group A of the Europa League, Arsenal and PSV Eindhoven occupy the first and second positions respectively.
Both sides have been impressive in their respective domestic leagues and are nearly unstoppable every time they take to the pitch.
PSV Eindhoven will host FC Zurich in a UEFA Europa League fixture at Philips stadion on Thursday night.
PSV Eindhoven will host Rangers in the second leg of their Champions League qualifying playoff at the Phillips Stadion on Wednesday night.
Rangers will host PSV Eindhoven in the first leg of their Champions League qualifying playoff round tie at the Ibrox stadium on Tuesday.
PSV Eindhoven will host Monaco in their second leg clash of the Champions League third round qualifier at the Philips Stadion on Tuesday.
At one point last season, Monaco securing a Champions League spot was unthinkable, however, the French side did well towards the end of the campaign to grab the third spot.
Ajax and PSV Eindhoven will face each other in the Dutch Super Cup final at the Johan Cruyff ArenA on Saturday.