The Serb made a commanding start to the match, breaking Tsitsipas' serve in his first service game.
It was a dominant victory for the American against one of the greatest ever to have ever played the game and that will give him a massive boost of confidence.
Novak Djokovic and Stefanos Tsitsipas will face one another in the group stage of the 2022 ATP Finals on Monday, November 14.
The top eight ranked players have qualified for the ATP Finals, with incumbent world number one Carlos Alcaraz missing out due to an injury.
The ATP Finals is undoubtedly one the most important and prestigious tournaments of a season, and the years have seen some great tennis superstars steal the show.
On Sunday, the 2022 ATP Hamburg Open final will feature top seed Carlos Alcaraz of Spain taking on Italian NextGen Lorenzo Musetti.
Roger Federer beat Rafael Nadal in the finals of the 2010 ATP World Tour Finals on this day 11 years ago and notched up an elite record in the process.
The in-form German player registered a straight-set victory over Daniil Medvedev to reign supreme in Turin.
Daniil Medvedev won the match against Casper Ruud in straight sets and recorded an impressive score of 6-4 6-2.
The Serbian World No.1 defeated Cameron Norrie to finish the round-robin stage with a perfect 3-0 record.