World no. 54 Marcos Giron will face world no. 77 Soonwoo Kwon in the first round of the 2022 Atlanta open.
On paper, Djokovic should have a simple victory against the Korean but you never know when it comes to tennis.
The most eye-catching fixture of all on the opening day was the one between Dusan Lajovic and fifth seed Frances Tiafoe.
The Spaniard did not let his guard down even once in the final set against Soonwoo Kwon and recorded a comfortable 6-1, 2-6, 6-2 victory.
The second seed arrived in Rotterdam after suffering a disappointing third-round defeat against Marin Cilic at the Australian Open in January.
The World No. 13, who did not drop a set en route to the title, was at his impressive best against the Spaniard on Sunday.