US tennis player and ninth seed Danielle Collins said her goodbyes as well after losing to compatriot Shelby Rogers.
Veteran tennis player and 19th seed Simona Halep also made a winning start to her 2022 Roland Garros campaign after a fine win over Germany's Nastasja Mariana Schunk.
Danielle Collins is making her maiden trip to the Round of 16 in Rome following two prior second-round defeats.
The Pole came back from a break down in each set, saving two set points in the first-set tiebreak, to win in 1 hour and 49 minutes.
The Polish player advanced to the semifinals against 2015 BNP Paribas Open champion Simona Halep after a 56-minute victory over Keys.
Former world number one Simona Halep defeated Emma Raducanu’s conqueror Danka Kovinic to cruise into the last 16 of the 2022 Australian Open.
Craig Tiley, the chief executive of the Australian Open, thinks there is still a lot to work out before Djokovic arrives in Australia.
The left-handed Spaniard will lead a strong field that also includes former World No.4 Kei Nishikori and former World No.5 Kevin Anderson.
Elsewhere, second seed Simona Halep had reversed a recent loss to Aliaksandra Sasnovich and reached the quarterfinals.
Marta Kostyuk beat Emma Raducanu 6-2 6-1 in under an hour at the WTA 250 event in Cluj-Napoca, with the Brit committing 41 unforced errors.