Djokovic and Nadal met in the semi-final of the competition last year, which saw the Serb emerge victorious after an epic battle.
Nadal came into the French Open with little experience on clay, having only played five matches on the surface this year.
The King of Clay advanced to the quarter-final where he will face world no. 1 Novak Djokovic, who beat Diego Schwartzman in straight-sets.
In an earlier interview with ATP, the Dutchman had said that Rafa was one of his idols, someone he was hopeful of meeting.
With form and confidence on his side, it looks like the 34-year-old is the man to beat for the highly anticipated tournament in the French capital.
Day six saw third seed Rafael Nadal eliminated by Canada's Denis Shapovalov who recorded a fantastic comeback win.
The Greek edged out a 6-3, 5-7, 7-6 (7-4) win against Grigor Dimitrov to make it through to the next round of the competition.
After beating second seed Alexander Zverev 6-3, 6-1, the 19-year-old mentioned that it was watching Rafa win this particular title as he was growing up that inspired him.
Today, Juan Carlos Ferrero, the man who Nadal beat 17 years ago to begin his rise in tennis, is Carlos Alcaraz's coach.
Although Nadal has been victorious so far in every single match he has played against Alcaraz, the 18-year-old is on one hell of a serious hot streak.