Real Madrid confirmed on Tuesday that French defender Ferland Mendy has a problem in his tibia, leaving him a doubt for this season.
Real Madrid scored a late equalizer against Sevilla at the Di Stefano stadium on Sunday night to secure a 2-2 draw.
Following yesterday's draw between Barcelona and Atletico, Real Madrid have a chance to jump to the top of the table.
Barcelona have missed out on the chance to go top of the league table in a tense but goalless draw with Atletico Madrid.
Atletico Madrid remain two points clear at the top of La Liga, but their draw at Barcelona means Real Madrid now hold the advantage.
Gianni Infantino, the FIFA president, has called for talks with the clubs but understands the need for sanctions.
It’s all to play for in Spain and the stakes could scarcely be higher.
The encounter is expected to be quite interesting considering the pressure on both these teams to get a win at any cost.
Sevilla's record in away league games against Real Madrid is not kind reading for the team.
Luis Suárez is Atletico Madrid's top scorer with 19 goals this season, and Marcos Llorente has also been in spectacular form with 12 goals.