Gerard Moreno has been in sensational form for Villareal, making his presence felt with excellent performances.
Atletico Madrid have won four of the last five La Liga games in Valladolid, drawing the last one in October 2019.
Four teams are in the race for La Liga, but only Atletico Madrid depend on themselves to win the competition.
Luis Suárez is Atletico Madrid's top scorer with 19 goals this season, and Marcos Llorente has also been in spectacular form with 12 goals.
Atletico Madrid maintain their slender lead at the top of the La Liga points table after a 0-1 victory against Elche on Saturday.