The 21-year-old got his name on the scoresheet in an emphatic 4-0 win over the Italians at Stamford Bridge.
Matchday five sees Liverpool host Porto at Anfield, with the top spot in Group B already secured thanks to four victories in the opening four matches.
The Blues secured a place in the Champions League last-16 and took control of the battle for the top spot in Group H.
De Gea played an important role in between the posts to help Manchester United defeat Villarreal 2-0 in the Champions League.
Manchester United secured progression to the knockout phase of this season’s Champions League with a game to spare.
The midfielder was restricted to just 30 appearances in all competitions during his first season with the Reds after signing from Bayern Munich.
The former Reds midfielder has been put in temporary charge of the first team following the departure of Ole Gunnar Solskjaer.
Following the departure of Ole Gunnar Solskjaer from the manager's position, Michael Carrick will be in charge of the game against Villarreal.
The Spaniard joined PSG on a free transfer in July after leaving Real Madrid but has been unable to play due to a long-running calf injury.