Having already qualified top of the group after beating Villarreal in their last match, the midweek game will mean more for the opponents than for the Red Devils.
Interim manager Ralf Rangnick believes the group closer against Young Boys is a great chance to get to know more of his players.
The German was assisted by technical director Darren Fletcher and first-team coach Kieran McKenna during his first match in charge.
Ralf Rangnick, head of sports and development at Lokomotiv Moscow, is being reported by various sources as the front-runner to become Manchester United’s interim manager.
After a debut 2020-21 season at Liverpool that was afflicted by injuries and COVID-19, Tsimikas has gained more regular opportunities in the team this term.
The Reds face their third match in the space of a week when Southampton visit Anfield on Saturday in the Premier League.
RB Leipzig’s win against Club Brugge in the other group match means that PSG are also through to the knockout phase.
Jesus' goal from Bernardo's delicate pass after 77 minutes inspired a 2-1 victory for Manchester City against PSG at the Etihad Stadium.
The Brazilian goalkeeper wore the armband for Wednesday night’s Champions League victory over FC Porto at Anfield.
The Reds made it five wins from five in Group B after second-half goals from Thiago Alcantara and Mohamed Salah against Porto at Anfield.