Manchester United have a difficult run of games coming, starting with Villarreal in the Champions League.
Roberto Di Matteo won Chelsea their maiden Champions League trophy in May 2012, but found himself sacked by the club 6 months later.
As he approaches the 100-appearance landmark for the club he signed up with at the age of eight, Loftus-Cheek will hope to become a regular for the team.
Liverpool and Ajax are through to the Champions League round of 16 with wins on Matchday 4; Manchester City, Real Madrid also register wins.
Liverpool will be facing Atletico Madrid in the reverse leg of the Champions League group match at Anfield.
Liverpool produced an impressive performance to get past Atletico 3-2 when the two sides met a couple of weeks ago.
Cristiano Ronaldo and Edinson Cavani scored the opening two goals, as Manchester United comfortably beat Spurs 3-0.
After producing a stunning comeback victory against Atalanta, Manchester United next take on arch-rivals Liverpool on Sunday.
The Chelsea Academy graduate scored the opener in the 4-0 win against Malmo in the Champions League, volleying home Thiago Silva’s cross.
The Reds maintained their unbeaten start to the 2021-22 campaign with a hard-fought victory in the Spanish capital over Atletico Madrid.