Lakshya Sen, who had claimed his maiden Super 500 title at India Open in January, lost 18-21, 15-21 in 57 minutes.
The 21-year-old Kiran George prevailed over fellow Indian Priyanshu Rajawat 21-15 14-21 21-18 to clinch the men's singles title.
Malvika took just over half an hour to dispatch 16-year-old Tasnim 21-13, 21-15 in the women's singles pre-quarterfinals.
In a one-hour and five-minute quarter-final match, PV Sindhu defeated her Thai opponent, who was ranked sixth in the event.
The decision taken by the Malaysian ace was confirmed by Badminton Association of Malaysia president Norza Zakaria.
At Lucknow's Babu Banarasi Das Indoor Stadium, HS Prannoy defeated Priyanshu Rajawat 21-11, 16-21, 21-18 in the second round.
After a slew of withdrawals reduced the men's singles draw to just three seeded players, the Verma brothers, Sameer and Saurabh, and Prannoy.
Recently, the Thai shuttler became Sindhu's bogey player, defeating the ace Indian shuttler for the fifth time in a row.
The 19-year-old from Gwangju, South Korea took just over 30 minutes to end PV Sindhu's hopes of a second year-end title with a 21-16, 21-12 win.
PV Sindhu, the reigning world champion, had to work hard to beat Yujin 14-21, 21-19, 21-14 in an hour and six minutes in the quarterfinal.