With the hosts fighting for the league title and the visitors battling to survive relegation, the match on Thursday will hold huge significance for both sides.
Sao Paulo are close to where they are expected to be in the standings, as they are in the hunt for the league title by sitting third in the table.
Last year, Tigre won the Primera Nacional title in the final match, thereby securing a ticket to the top division of the Argentine football league system.
Athletico PR are only four points behind their visitors, hence a victory in the upcoming clash can close down that gap significantly.
Reigning champions River Plate have not had the start they would have imagined so far this season, having gone winless in the opening two encounters.
Juventude are enduring a season to forget, having managed to accumulate only 10 points from 11 games to sit in the 19th spot.
Mexico hold the superiority in the FIFA rankings, sitting ninth in the table, while Jamaica are way behind at the 64th spot.
As it stands, El Salvador are top of Group D with four points from two games and the USA are second with three points from one match.
Gareth Southgate's side are yet to win a single game in the ongoing competition and are sitting at the bottom of League A Group 3.
The FIFA rankings are heavily in favour of Turkey, who are ranked at 43rd spot, while Lithuania are way behind at 138th place.