The 21-time Grand Slam winner will vie for his fourth title in 2022 before the French Open in Paris.
Vaccine passports will no longer be required to enter venues beginning March 14, according to Prime Minister Jean Castex.
The Australian Open 2022 finalist became the 27th man to reach the top spot since computerized rankings began in 1973.
The Russian, who was a finalist at the Australian Open 2022, will be officially crowned the new men's No.1 on Monday.
The 34-year-old fell short against 123rd-ranked Jiri Vesely, losing the match 6-4, 7-6 in one hour and 57 minutes.
The World No.1 had earlier said that he is willing to pay the price for his unvaccinated status.
Novak Djokovic defeated Italy's Lorenzo Musetti 6-3, 6-3 to progress to the second round of the Dubai Duty Free Tennis Championships.
The World No.1 will feature in Duty Free Tennis Championships after being deported from Australia ahead of the first Grand Slam of the Year.
In the new interview with BBC, the tennis star claims that he is not anti-vaccination, a claim that appears to contradict previous statements.
Rafael Nadal's rivalries with Novak Djokovic and roger Federer are legendary.