The World No.1 was recently denied a chance to defend his title at Australian Open 2020 due to his Covid-19 vaccine status.
The Spaniard bettered the record of Roger Federer, Rafael Nadal and Novak Djokovic at a Grand Slam event.
Daniil Medvedev defeated Switzerland’s Henri Laaksonen with ruthless efficiency to go through to the second round of the 2022 Australian Open.
Djokovic is the current French Open champion, and his absence from the tournament would preclude him from retaining his title.
The Serbian winner expressed his hope that attention will now shift back to tennis and the Australian Open Grand Slam, which begins Monday.
A federal court on Sunday upheld the Australian immigration minister cancelling the visa for Novak Djokovic, meaning he will be deported.
The Serb's chances of winning a record-breaking tenth title in Melbourne are in jeopardy after his visa was cancelled twice.
Australian immigration minister Alex Hawke asserted that the government will stand by its measures to curb the pandemic.
The World No.1 has been drawn against his Serbian compatriot Miomir Kecmanović for the first round.
Djokovic stands one major championship win away from setting the men's record with 21 Grand Slam titles.