While Morocco won their last two games in the competition, Spain are heading into this contest on the back of a two-match winless run.
Defying the odds, Morocco started the tournament with a draw over Croatia before defeating Belgium and Canada to top the group with seven points.
Morocco will be aiming to secure a place in the last-16 of Qatar World Cup when they take on Canada in their final Group F encounter at Al Thumama Stadium on Thursday
Belgium were far from convincing in their opening match of the 2022 World Cup match against Canada on Wednesday, but managed to secure a narrow 1-0 win.
Belgium will be looking to put one step in the knockout stages of the World Cup when they take on Morocco in a Group F fixture at Al Thumama Stadium on Sunday.
Morocco and Croatia will be commencing their FIFA World Cup 2022 journeys at Al Bayt Stadium on Wednesday.
Morocco will round off their preparations for the upcoming FIFA World Cup in Qatar with a friendly against Georgia at the Sharjah stadium on Thursday.
World Cup bound side Morocco will continue their preparations for the global event as they visit Benito Villamarin Stadium in Spain on Tuesday to take on Paraguay.
Liberia will host Morocco in an AFCON qualification group stage fixture at Stade Mohammed V on Monday.