The 28-year-old was last seen in action in a 2-2 draw with Atalanta in early November before suffering an injury while on international duty.
The full-back had made 35 appearances in three seasons at United before 2021/22, however, his fortunes seem to have been changed now.
The young English forward was at the end of a few bright moments in attack as the Reds were 0-0 with the visiting team during his substitution.
The agreement is most likely to be a loan until the end of the season, as Napoli does not have the option of making it permanent.
The restoration to the starting XI saw Jones make a memorable comeback, as the English centre-back was one of the few positives for United.
Wolves outplayed United in almost every department and were the better team for most parts of the game. They were full value for the three points.
Manchester United suffered a shock Premier League defeat against Wolves at Old Trafford on Monday.
Ahead of the tricky encounter with Wolves, Rangnick emphasised the importance of keeping the unbeaten eight-game stretch going.
At the age of 36, there were a lot of doubts about whether Ronaldo can live up to the expectations, but the former Real Madrid forward has silenced his critics in some style.
Cavani came off the bench to score the equaliser at St James’ Park before starting in the victory over Burnley last time out.