Swiatek wrote her name in the history books when she became the lowest-ranked woman to win the French Open the previous year at rank 54.
Wawrinka, who has a 44-15 record in the French Open, won the title back in 2015 and finished runner-up on the Parisian terre battue in 2017.
She had sustained a tear in her left calf during her recent Italian Open Round of 32 match against German player Angelique Kerber in Rome.
The Austrian player suffered a shock 6-3, 6-2 defeat against Cameron Norrie at Lyon Open on Thursday.
Andre Agassi became the first player since Rod Laver to win the career slam in the Open Era as he clinched the French Open.
Rafael Nadal won his first French Open in 2005 and established a run that would see him win the title 13 times.
The French Open 2021 will see fans at the three main courts but only at a capacity of 35% of the original capacity.
Rafael Nadal eases past Federico Delbonis to reach the third round of the Monte Carlo Masters, to play Grigor Dimitrov next
French Tennis Federation president Gilles Moretton said that at the moment, the French Open 2021 would go on as planned.