Keys has appeared in one Grand Slam tournament final, the 2017 US Open, as well as the 2016 WTA Finals and the 2016 Summer Olympics.
Keys has used her aggressive playing style to become one of the pioneers of the next generation of American tennis.
She has won six WTA tournaments, five of which were at the Premier level, with her most recent victory coming at the 2019 Cincinnati Open, a Premier 5 event.
Jessica Pegula and Madison Keys are scheduled to face each other in the quarterfinals of the 2022 WTA San Diego Open on Friday, October 14.
Kasatkina and Keys have faced each other a total of eight times in the past with the American coming out on top in seven matches.
Madison Keys and Viktorija Golubic are scheduled to face each other in the round of 32 of the 2022 Tallinn Open on Monday, September 26.
Gauff, the 12th seed, is the second-youngest player still in the women's draw, yet she's largely regarded as one of the favourites to win the US Open.
Keys will have home support backing her at the US Open and she will be hoping to make it count when the time comes.
On Saturday, the semifinal of the 2022 WTA Cincinnati Open will feature World No. 24 Madison Keys of the United States taking on World No. 28 Petra Kvitova of the Czech Republic.
The 24th-ranked Madison Keys will be Iga Swiatek's opponent in the third round of the 2022 WTA Cincinnati Open on Thursday.