18-year-old Spaniard Carlos Alcaraz, ranked 55th in the world, upset No. 3 Stefanos Tsitsipas, 6-3, 4-6, 7-6, 0-6, 7-6 to advance to the fourth round of the 2021 US Open.
The Czech star fired 24 aces and saved a match point on her way to beat Bianca Andreescu in a thrilling three-set encounter.
Arthur Ashe became the first black player in the history of Tennis to win Grand Slam titles.
Sania Mirza and Coco Vandeweghe were eliminated after losing to Raluca Olaru and Nadiia Kichenok in a women's doubles first-round match at the US Open.
Novak Djokovic moves one victory closer to becoming the first male player to win the Grand Slam since Rod Laver in 1969.
Stefanos Tsitsipas dismissed 44th-ranked Frenchman Adrian Mannarino, ducking both the heavy rain and his opponent’s offbeat lefty game.
Sloane Stephens held her ground, dictating the proceedings to defeat the 21st seed, 6-4, 6-2, in one hour and eight minutes.
The Serbian World No.1 lost the second set, but came back strongly to win the remaining sets against Holger Vitus Nodskov Rune.
Murray was heard speaking to the chair umpire during the match where he was complaining about the length of time Tsitsipas was off the court.
Coco Gauff survived a scare before going past Magda Linette with a 5-7, 6-3, 6-4 victory at the US Open.