Karim Benzema scored a second-half hat-trick as Real Madrid came from behind to beat Paris Saint-Germain 3-1 in the Champions League last-16 second leg fixture.
Pochettino believes that his team cannot look to defend their lead and must go out looking to kill the tie off.
The French forward will be a hot-property in the summer transfer window and is expected to seal a move to Spanish giants Real Madrid.