Having already qualified top of the group after beating Villarreal in their last match, the midweek game will mean more for the opponents than for the Red Devils.
Interim manager Ralf Rangnick believes the group closer against Young Boys is a great chance to get to know more of his players.
The German was assisted by technical director Darren Fletcher and first-team coach Kieran McKenna during his first match in charge.
A late Fred goal helped Manchester United continue their recent positive results with a crucial 1-0 victory over Crystal Palace.
A heavy 4-1 defeat against Watford ended Ole’s reign at the club. Since then Michael Carrick was given the caretaker responsibility.
Rangnick has started his role as Manchester United's new interim manager for the remainder of the season after his work permit and necessary paperwork were approved.
Carrick managed Manchester United in the last two matches, with the Red Devils winning one and drawing another.
Manchester United have officially appointed Ralf Rangnick as interim manager till the end of the season and then as a consultant for a further two years.
Ralf Rangnick's contract will see him take charge of the first team until June and then remain at the club for at least a further two years in a consultancy role.
Ralf Rangnick, head of sports and development at Lokomotiv Moscow, is being reported by various sources as the front-runner to become Manchester United’s interim manager.