Southampton will host Nottingham Forest in a crucial bottom of the Premier League table clash at St Mary’s Stadium on Wednesday night.
Nottingham Forest will host Chelsea in a Premier League fixture at City Ground on Sunday.
Manchester United are only four points behind fourth-placed Tottenham Hotspur having played two games less.
Manchester United resumed their competitive action last midweek when they defeated Burnley 2-0 in the EFL Cup.
For Nottingham, this will be their first game in competitive football since domestic leagues took a break due to the unusual winter World Cup.
The World Cup break had come at the wrong time for Nottingham Forest, who were on a three-match unbeaten streak in all competitions.
Forest are unbeaten in their last three domestic matches and have won two of them, including a EFL Cup win over Tottenham Hotspur.
Olympiacos will host Nottingham Forest in a friendly fixture at Karaiskakis Stadium on Saturday.
Nottingham Forest will continue their friendly schedule when they take on Greek Super League side Atromitos at the Karaiskakis Stadium in Athens on Tuesday evening.
Both these sides have played each other a few times in this competition history and Nottingham Forest have a better record in EFL Cup against Spurs.