With the second leg happening at Old Trafford, Erik ten Hag’s side will undoubtedly be the favourites to get the job done in this game.
Despite Christian Eriksen’s injury setback, Man United are expected to name a strong Starting XI to see out the job in this contest.
Eddie Howe's side will be entering this game on the back of registering a 1-0 victory in the first leg away from home.
Newcastle United’s position in the Premier League table and their impeccable defensive record makes it difficult for any side to beat them.
After losing two points against Crystal Palace in a 1-1 draw, leaders Arsenal scored in the dying seconds to get the three points against United on Sunday.
Manchester United are sitting fourth in the Premier League table with 39 points from 20 matches. Nottingham Forest are sitting 13th with 21 points from 20 games.
Newcastle have defied all the odds to be deservedly sitting third in the Premier League table with 39 points from 20 games.
The bottom-placed Saints have performed well below-par this campaign. With just 15 points from 20 games, they are placed at the 20th spot in the table.
The away victory to Crystal Palace in the FA Cup match at the weekend will act as a confidence-booster for Southampton.
Southampton are placed at the bottom of the league table with just 12 points from 18 games. They have only won three of those matches all season.