For Arsenal, this game is largely about getting revenge on the only side that has beaten them in the league this campaign.
Manchester United nearly made it 10 wins in a row in all competitions, however, a late draw at Crystal Palace forced them to end that winning streak.
Tottenham Hotspur will host Arsenal in a Premier League fixture at the Tottenham Hotspur Stadium on Sunday evening.
Meanwhile, Oxford United are going through an inconsistent season in League One. They are currently placed 15th with 29 points from 24 games.
The Gunners have been deserved leaders till now, while Newcastle have surprised many to be currently placed in the top four positions.
The Gunners have been excellent this campaign, losing just once so far in the league against Manchester United at Old Trafford.
Brighton & Hove Albion will host Arsenal in an English Premier League fixture on Saturday.
After taking over the club in 2019, Arteta has urged supporters to have faith in the process, which is now showing results.
Mikel Arteta would want Arsenal to continue from where they left off before the Premier League season was halted due to the World Cup break.
Sitting 16th in the table, David Moyes’ side only have 14 points from 15 matches. They are just a point above 18th-placed Nottingham Forest.