Manchester City are second in the Premier League table with 39 points from 18 games. They are currently eight points behind leaders Arsenal.
Tottenham Hotspur are fifth in the Premier League table and have 33 points from 19 matches. They are five points behind fourth-placed Manchester United.
For Manchester United, the game on Saturday evening is all about getting revenge on their city rivals.
When these two clubs faced earlier this season at the Etihad Stadium, Pep Guardiola’s side comfortably won 6-3.
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The away victory to Crystal Palace in the FA Cup match at the weekend will act as a confidence-booster for Southampton.
Southampton are placed at the bottom of the league table with just 12 points from 18 games. They have only won three of those matches all season.
Man City are sitting second in the EPL table with 39 points from 17 games, while Chelsea are placed 10th with 25 points from the same number of matches.
Premier League heavyweights Manchester City and Chelsea will go head-to-head in a FA Cup third round fixture at Etihad Stadium on Sunday.