Heading into Thursday's match, all questions will be about Cristiano Ronaldo’s participation following his refusal to come on as a substitute in the win over Tottenham.
PSV Eindhoven have been on a decent run domestically as they are placed second in Eredivise with 24 points from 11 games.
Freiburg have already qualified for the league's knockout stages with games remaining, whereas Olympiacos are out of the Europa League
Placed in Group A of the Europa League, Arsenal and PSV Eindhoven occupy the first and second positions respectively.
Both sides have been impressive in their respective domestic leagues and are nearly unstoppable every time they take to the pitch.
Jose Mourinho’s side have 19 points from nine games to sit sixth in the table. They are five points behind leaders Atalanta who have played one extra game.
Real Betis will host AS Roma in a UEFA Europa League fixture at Benito Villamarin on Thursday.
The horrific start to the Premier League season now seems a distant memory for Manchester United. They have won seven of their last nine matches in all competitions.
In the Europa League, Sociedad have been mighty impressive by sitting at the top of Group E with nine points from three matches.
In Group E, Omonia have lost both their matches to sit at the bottom spot, while United are second with three points from two games.