Denis Shapovalov beat Zverev 6-3, 7-6(5), 6-3 to book a spot in the quarterfinals of the Australian Open, where he will face Rafael Nadal.
Rafael Nadal beat Adrain Mannarino 7-6(14), 6-2, 6-2 to book his spot in the last eight of the opening Grand Slam of the season.
All of Barbora Krejcikova, Madison Keys and Jessica Pegula qualified for the Australian Open quarterfinals on Sunday (January 23).
It was a mixed day in the Australian Open as a few notable names exited the tournament even as other seeded players marched on.
In a free-hitting show on Margaret Court Arena, the Croatian blasted forehands and hammered backhands to end Rublev's time in Australia
After a good start, Jannik Sinner struggled to find his range from the baseline in the second set of the match.
Daniil Medvedev beat Botic van de Zandschulp 6-4, 6-4, 6-2 to make it into the fourth round of the Australian Open 2022.
Rafael Nadal had not competed in a tour-level event since August, when he suffered a foot injury in Washington.
The pair's only previous meeting was a five-set first-round battle at the 2019 US Open, which Alexander Zverev won.
Emma Raducanu exited the 2022 Australian Open after losing to unseeded Danka Kovinic in the second round match on Thursday.