Camila Giorgi defeated Zhang Shuai and Yulia Putintseva in the first round before knocking out No. 7 seed Aryna Sabalenka.
US tennis player and 11th seed Jessica Pegula emerged victorious in her third round match against Tamara Zidansek.
World No.1 Ashleigh Barty demolished Italian qualifier Lucia Bronzetti 6-1, 6-1 on Wednesday to enter the third round of 2022 Australian Open.
Fans might have been hopeful of a tight encounter but Medvedev dominated the entire game and secured a vital win.
Camila Giorgi's father was involved in more controversy after the chair umpire requested security.