Michael Masi was fired as part of the FIA's sweeping changes to the sport following the contentious ending to the 2021 Abu Dhabi GP.
Alfa Romeo had a poor 2021 season, scoring a total of only 13 points and finishing ninth in the constructor's standings.
Latifi was subject to a flurry of hate messages and death threats on social media after his crash the final race of 2021.
Lewis Hamilton and Max Verstappen had a heated rivalry in 2021 and the controversial ending in Abu Dhabi would not have helped matters.
Speaking at the car launch of the F1-75, Charles Leclerc said he was happy with how the team have worked on their new F1 car.
Masi will be replaced by Eduardo Freitas and Niels Wittich, and a series of new structures, including a stand-alone race control unit.
Nikita Mazepin was unable to score a point in 2021, as was Mick Schumacher in the underdeveloped Haas VF-21.
George Russell, who has been in Formula 1 for three years now, is the first Mercedes junior driver to graduate for the works team.
One issue that has gone unnoticed until now as the sport transitions from 13 to 18-inch tyres that might cause some issues.
It had been hoped and expected that the race's chapter would be closed at a meeting of the F1 Commission on Monday.