Aiden Markram was the aggressor in a brilliant partnership with Rassie van der Dussen, scoring 51 runs off just 26 deliveries.
Quinton De Kock was one of a number of South Africa players who had not been taking the knee ahead of recent internationals.
West Indies managed to overcome South Africa to level the series thanks to Kieron Pollard's 51 and Dwayne Bravo's 4/19.
South Africa beat West Indies by one run to take a 2-1 lead in the T20 series courtesy of Quinton de Kock's 72 and Tabraiz Shamsi's economical spell.
Keshav Maharaj became the first South African bowler after 60 years to take a hat-trick in Tests.
AB de Villiers might end his three-year international retirment and come back for the series against the West Indies.