For Suyash Jadhav, it is his 2nd Paralympic Games, while Niranjan Mukundan and Prachi Yadav will be making their bow at the biggest stage for the first time in Tokyo.
18-year-old Kashish Lakra fought against improbable odds to qualify and compete against some of the best in the world.
He is a two-time World Championship silver medallist in the F51 club and one of the strong medal hopeful for the country.
Pal Szekeres is a former Hungarian fencer who first won a bronze medal at the Seoul Olympics in 1988 and a Gold at the 1992 Paralympics.
Pramod Bhagat has left no stone unturned in his preparation and is gunning for glory at the Tokyo Paralympics.
Hospitals in Japan's capital are being overstretched as the country battles its worst wave of COVID-19 infections, driven by the Delta variant.
It will be a historic Paralympics for India as the country will field its largest-ever team, with 54 athletes set to compete in nine sports.
Jhajharia himself had won gold in javelin throw twice, at the 2004 Athens Paralympics and the 2016 Rio Paralympics.
Indian athletes have appeared in every edition of the Summer Paralympics since 1984 though they made their official debut at the 1968 Summer Paralympics.
With excitement at a fever pitch, thousands of Paralympic athletes worldwide are gearing up to compete in 539 events across 22 sports.