Lille travel to Stamford Bridge to take on the defending champions in the first leg of the last-16 tie on Tuesday.
Chelsea defeated Palmeiras 2-1 in the FIFA Club World Cup final to lift the trophy for the first time in their history.
Chelsea needed extra-time and a late Kepa Arrizabalaga penalty save to see off Plymouth Argyle in the FA Cup in their fourth-round match.
Thomas Tuchel is isolating and was not with the squad for Chelsea's FA Cup fourth-round tie against Plymouth Argyle.
Callum Hudson-Odoi stated that it has been difficult to fully rest and recover in the days between midweek and weekend matches.
Thomas Tuchel reserved special praise for Hakim Ziyech's opener, which saw him curl an outrageous looping shot into the back of the net.
Chelsea, who are winless in four Premier League games, host Tottenham Hotspur on Sunday aiming to get back to winning ways.
Chelsea will face Spurs for the third time in January after beating them twice in the two legs of the Carabao Cup semi-final.
Chelsea boss Thomas Tuchel felt his “boys needs some days off” after the 1-1 Premier League draw against Brighton & Hove Albion on Tuesday.
Chelsea’ winless run in the Premier League continues as they were held to a 1-1 draw by Brighton & Hove Albion at Falmer Stadium on Tuesday.