The US Open has seen fewer streaks of dominance from the likes of Roger Federer, Novak Djokovic and Rafael Nadal.
Djokovic has already won three Grand Slams this year and will be looking to complete a calendar-year Grand Slam at the US Open.
Having already missed the Wimbledon and the Tokyo Olympics, the four-time US Open champion will also miss the final Grand Slam of the year.
Venus Williams is a two-time winner at Flushing Meadows (2000, 2001) and has competed in the event every year since 2006.
Federer shares the men's record of 20 Grand Slam titles with Rafael Nadal and Novak Djokovic, has had knee surgery twice in 2020 that made him go into rehabilitation for a year bef...
He withdrew from the Tokyo Olympics over his fitness issues and will also not be a part of the ATP Toronto and the Cincinnati Masters.
Serena Williams on Thursday added her name to the growing list of tennis stars to pull out of the Western and Southern Open.
Novak Djokovic and Rafael Nadal are in contention for a 21st Grand Slam title when they go to the US Open.
On winning the Olympic gold, something her idols Hingis and Federer failed to do, she said, "I think I accomplished it for them."
With many big names pulling out of the Tokyo Olympics, the Serbian was expected to walk away with the gold medal, but Alexander Zverev had other ideas.