Cleveland led going into the fourth quarter, fell behind by three, then went on a 14-2 run to take a comfortable lead.
Giddey acknowledged that the milestone was "cool" after the game, however, made it clear that he would have preferred to walk away with a win.
Jalen Green became the first teenager with a 30 point game in Rockets history and also tied the record for most 3s in a game by a teenager.