Barcelona are heavy underdogs at home against a team that has given them nightmares in the past, including that 8-2 defeat last year.
Memphis Depay scored a hat-trick as the Netherlands produced an irresistible display, while an Antoine Griezmann-inspired France opened up a greater lead.
France were forced to fight back to salvage a draw following an outstanding first-half strike from Ukraine's Mykola Shaparenkoto.
San Mames is never an easy place to win, with Barcelona struggling at the venue in recent seasons of La Liga as well.
FC Barcelona were finally able to register Memphis Depay, Eric Garcia and Rey Manaj for the 2021-22 season - thanks to Gerard Pique.
The club has sold a few players this season but their overall wage bill is still a whopping 200 million euros over the salary cap.
Patrik Schick scored his fourth goal of Euro 2020 as the Czech Republic beat a ten-man Netherlands to reach the quarter-finals.
This will be the first meeting between the Netherlands and the Czech Republic since 2015, the Dutch were beaten 3-2 back then.
Not long ago, Paulinho surprisingly moved to Camp Nou in 2017 and enjoyed a stellar campaign. Four years later, he is not ruling out a second stint.
Netherlands ended the Euro 2020 group stages with a well-taken 3-0 win over North Macedonia at Amsterdam on on Monday (June 21).