South Africa has last featured in a T20I recently against England and will be looking to make the most of their experience at the venue.
The venue will be competitive but the teams batting second have traditionally enjoyed more success.
Simi Singh became the first batsman in the No.8 position to hit a century in ODIs.
Ireland's opening pair of Paul Stirling and Balbrinie continued their solid form. They had put on a 64-run stand before Stirling was knocked over by Keshav Maharaj (1/50) for 27