Earlier this summer, Cristiano Ronaldo made a sensational return to Manchester United from Italian giants Juventus.
De Gea has now moved up in the all-time appearances chart at the club, with Alex Stepney being the only keeper ahead of him in this respect.
Other notable ties include Atletico Madrid against Bayern Munich, Inter Milan against Ajax, and Villareal vs Manchester City.
The first half was not quite as exciting as United's first game against Palace last week, with Telles' free kick being tipped onto the bar.
Fernandes scored the opener before Cristiano Ronaldo netted a double, as Manchester United came from behind to beat Arsenal 3-2.
Cristiano Ronaldo has scored 800 goals in his career during Manchester United's win against Arsenal in the Premier League.
Cristiano Ronaldo rifled the penalty right down the centre of the goal, bulging the net to bag his second of the night and Manchester United’s third with 20 minutes to go.
Lionel Messi has won the men’s Ballon d’Or for a record seventh time ahead of Robert Lewandowski and Jorginho.
The 2022 FIFA World Cup in Qatar is sure to be without Italy or Portugal as both teams were drawn in the same bracket on Friday.
Cristiano Ronaldo is in real danger of not being a part of the 2022 World Cup, thanks to Portugal's luck of the draw for the play-offs.