The second seed, who earned both his 50th tour-level victory of the season and 300th tour-level career win this week, was at his impressive best on Saturday.
Andy Murray beat world No.10 Hubert Hurkacz at the Erste Bank Open in Vienna.
Felix Auger-Aliassime reached his first Grand Slam semifinal after Carlos Alcaraz retired following the fourth game of the second set in Arthur Ashe Stadium.
The Greek star, considered one of the challengers for the Grand Slam title, suffered a stunning five-set loss in the third round of the US Open.
18-year-old Spaniard Carlos Alcaraz, ranked 55th in the world, upset No. 3 Stefanos Tsitsipas, 6-3, 4-6, 7-6, 0-6, 7-6 to advance to the fourth round of the 2021 US Open.
Stefanos Tsitsipas dismissed 44th-ranked Frenchman Adrian Mannarino, ducking both the heavy rain and his opponent’s offbeat lefty game.
The Spaniard teen, who will turn 18 on Wednesday, will take on his countryman in the second round of the Madrid Open.