Barcelona needed a late equalizer from make-shift forward Ronald Araujo at Camp Nou on Monday to earn a point against Granada.
Swiss champions Young Boys came from behind to beat Manchester United 2-1 in Bern on Tuesday after Aaron Wan-Bissaka was sent off.
Barcelona are heavy underdogs at home against a team that has given them nightmares in the past, including that 8-2 defeat last year.
Thirteen clubs from Europe's top leagues wanted to form a breakaway European competition earlier in the year.
Miralem Pjanic has joined Turkish side Besiktas on a one-year loan with no option to buy after hardly featuring for Barcelona in his first season at the club.
The full-back joined Spurs late in the summer transfer window from the Catalan giants after making three appearances for the Spanish side.
Prior to joining Sevilla in 2019, Luuk de Jong played five years in the Dutch League with PSV Eindhoven, scoring an impressive 74 goals.
Griezmann has returned to Wanda Metropolitano on a season long loan deal with an obligation to make the move permanent for around 40 million euros in the future.
Nuno Mendes arrives on loan, with option to buy, from Sporting CP until 30 June 2022.
Saul has up until now spent his entire club career in Madrid in his native Spain, having begun his youth career at Real Madrid before switching to Atletico.