Van de Zandschulp led 4-3 in the first set, and Rune was serving at 40/15 when he quit due to a sore chest.
The Norwegian's defeat came at the hands of Dutch player and eighth seed Botic van de Zandschulp.
The match of the day was undoubtedly played between Alex Molcan and Norbert Gombos with the scoreline reading 6-1, 3-6, 7-6 (9-7).